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1

Thermodynamics of nucleic acids and their interactions with ligands

Lane, Andrew N., Jenkins, Terence C.

Journal:

Quarterly Reviews of Biophysics

Year:

2000

Language:

english

File:

PDF, 724 KB

english, 2000

2

A Molecular Anchor for Stabilizing Triple-Helical DNA

Keith R. Fox, Paolo Polucci, Terence C. Jenkins and Stephen Neidle

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

3

Inhibition of Bacteriophage T7 RNA Polymerase in Vitro Transcription by DNA-Binding Pyrrolo[2,1- c ][1,4]benzodiazepines †

Puvvada, Madhu S., Forrow, Stephen A., Hartley, John A., Stephenson, Pauline, Gibson, Ian, Jenkins, Terence C., Thurston, David E.

Journal:

Year:

1997

Language:

english

File:

PDF, 334 KB

english, 1997

4

Locus-Specific Microemulsion Catalysts for Sulfur Mustard (HD) Chemical Warfare Agent Decontamination

Fallis, Ian A., Griffiths, Peter C., Cosgrove, Terence, Dreiss, Cecile A., Govan, Norman, Heenan, Richard K., Holden, Ian, Jenkins, Robert L., Mitchell, Stephen J., Notman, Stuart, Platts, Jamie A., R

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

5

Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones

Melanie D. Keppler, Martin A. Read, Philip J. Perry, John O. Trent, Terence C. Jenkins, Anthony P. Reszka, Stephen Neidle, Keith R. Fox

Journal:

Year:

1999

Language:

english

File:

PDF, 937 KB

english, 1999

6

Design, Synthesis, and Evaluation of Novel Biarylpyrimidines: A New Class of Ligand for Unusual Nucleic Acid Structures

Wheelhouse, Richard T., Jennings, Sharon A., Phillips, Victoria A., Pletsas, Dimitrios, Murphy, Peter M., Garbett, Nichola C., Chaires, Jonathan B., Jenkins, Terence C.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

7

Effects of substituted 2-nitroimidazoles and related compounds on unscheduled DNA synthesis in rat hepatocytes and in non-transformed (BL8) and transformed (JB1) rat liver epithelial derived cell lines

Mohammad Suzangar, Ian N.H. White, Terence C. Jenkins, Thomas A. Connors

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 618 KB

english, 1987

8

Polyfunctional Radiosensitizers: VII. Radiosensitization by Conformationally-Restricted Isomers of a Nitroxyl Biradical in Vitro

Barbara C. Millar, Terence C. Jenkins, C. E. Smithen and Sally Jinks

Journal:

Radiation Research

Year:

1985

Language:

english

File:

PDF, 421 KB

english, 1985

9

Two new cyclosporin folds observed in the structures of the immunosuppressant cyclosporin G and the formyl peptide receptor antagonist cyclosporin H at ultra-high resolution

Potter, Brian, Palmer, Rex A., Withnall, Robert, Jenkins, Terence C., Chowdhry, Babur Z.

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 345 KB

english, 2003

10

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization

Geoffrey Wells, Marie Suggitt, Marissa Coffils, Mirza A.H. Baig, Philip W. Howard, Paul M. Loadman, John A. Hartley, Terence C. Jenkins, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 212 KB

english, 2008

11

Genotoxicity studies on DNA-interactive telomerase inhibitors with application as anti-cancer agents

Dean J. Harrington, Eduardo Cemeli, Joanna Carder, Jamie Fearnley, Sian Estdale, Philip J. Perry, Terence C. Jenkins, Diana Anderson

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

12

Molecular Modelling of a Sequence-specific DNA-binding Agent Based on the Pyrrolo[2, 1-c][1,4]benzodiazepines

LESLEY J. ADAMS, TERENCE C. JENKINS, LEE BANTING, DAVID E. THURSTON

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

13

Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs

Tanious, Farial A., Jenkins, Terence C., Neidle, Stephen, Wilson, W. David

Journal:

Year:

1992

Language:

english

File:

PDF, 978 KB

english, 1992

14

The Effect of Combinations of Nitroaromatic and Nitroxyl Radiosensitizers on the Radiation Survival Response of Chinese Hamster Cells, V.79-753B, in Vitro

Barbara C. Millar, E. Martin Fielden and Terence C. Jenkins

Journal:

Radiation Research

Year:

1981

Language:

english

File:

PDF, 672 KB

english, 1981

15

Sequence-Selective Interaction of the Minor-Groove Interstrand Cross-Linking Agent SJG-136 with Naked and Cellular DNA: Footprinting and Enzyme Inhibition Studies †

Martin, Chris, Ellis, Tom, McGurk, Claire J., Jenkins, Terence C., Hartley, John A., Waring, Michael J., Thurston, David E.

Journal:

Year:

2005

Language:

english

File:

PDF, 775 KB

english, 2005

16

The use of anti-obesity medications in people with mental illness as an adjunct to lifestyle interventions â Effectiveness, tolerability and impact on eating behaviours: A 52-week observational study

Tham, Marlene, Chong, Terence W.H., Jenkins, Zoe M., Castle, David J.

Journal:

Obesity Research & Clinical Practice

Year:

2020

File:

PDF, 68 KB

2020

17

Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box

Federico Brucoli, Rachel M. Hawkins, Colin H. James, Geoff Wells, Terence C. Jenkins, Tom Ellis, John A. Hartley, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 488 KB

english, 2011

18

Solution Structure of a 2:1 C2-(2-Naphthyl) Pyrrolo[2,1- c ][1,4]benzodiazepine DNA Adduct: Molecular Basis for Unexpectedly High DNA Helix Stabilization †‡

Antonow, Dyeison, Barata, Teresa, Jenkins, Terence C., Parkinson, Gary N., Howard, Philip W., Thurston, David E., Zloh, Mire

Journal:

Year:

2008

Language:

english

File:

PDF, 2.03 MB

english, 2008

19

Supplement: Special Issue Commemorating the 75th Anniversary of the Center for Radiological Research || Dual-Function 2-Nitroimidazoles as Hypoxic Cell Radiosensitizers and Bioreductive Cytotoxins: In Vivo Evaluation in KHT Murine Sarcomas

Shirley Cole, Ian J. Stratford, Gerald E. Adams, E. Martin Fielden and Terence C. Jenkins

Journal:

Radiation Research

Year:

1990

Language:

english

File:

PDF, 314 KB

english, 1990

20

Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers

Bose, D. Subhas, Thompson, Andrew S., Smellie, Melissa, Berardini, Mark D., Hartley, John A., Jenkins, Terence C., Neidle, Stephen, Thurston, David E.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1992

Language:

english

File:

PDF, 373 KB

english, 1992

21

Factors involved in guanine/cytosine (G/C) selectivity of DNA-binding drugs: a molecular modelling study of ligand interactions with a tyrT DNA sequence

Greenidge, Paulette A., Laughton, Charles A., Jenkins, Terence C., Neidle, Stephen

Journal:

Journal of the Chemical Society Faraday Transactions

Year:

1993

Language:

english

File:

PDF, 771 KB

english, 1993

22

Inorganic energetics from mainframe to 'back of envelope'

Jenkins, Harry Donald Brooke, Kemp, Terence J.

Journal:

Science Progress

Year:

2009

Language:

english

File:

PDF, 540 KB

english, 2009

23

Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs

Burke, Philip J., Wong, Lai Chun, Jenkins, Terence C., Knox, Richard J., Meikle, Ian T., Stanforth, Stephen P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 465 KB

english, 2016

24

Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine–DNA alkyltransferase: implications for the design of DNA-modifying drugs

Dimitrios Pletsas, Richard T. Wheelhouse, Vassiliki Pletsa, Anna Nicolaou, Terence C. Jenkins, Michael C. Bibby, Soterios A. Kyrtopoulos

Journal:

European Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 419 KB

english, 2006

25

Acyl nitroxides. Part 2. Reactions with hydrocarbons

Hussain, S. Altaf, Jenkins, Terence C., Perkins, M. John, Siew, Nancy P. Y.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1979

Language:

english

File:

PDF, 785 KB

english, 1979

26

Preparation and Chemical and Biological Studies of the Novel Complex

Wagner M. Teles, Flávia C. Machado, Carlos A. Montanari, Carlos A. L. Filgueiras, Terence C. Jenkins

Journal:

Transition Metal Chemistry

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

27

AT selectivity and DNA minor groove binding: modelling, NMR and structural studies of the interactions of propamidine and pentamidine with d(CGCGAATTCGCG)2

Terence C Jenkins, Andrew N Lane

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1997

Language:

english

File:

PDF, 556 KB

english, 1997

28

Acyl nitroxides. Part 3. Reactions with phenols, alcohols, ethers, and sulphides

Hussain, S. Altaf, Jenkins, Terence C., Perkins, M. John

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1979

Language:

english

File:

PDF, 779 KB

english, 1979

29

An Extended Pyrrolobenzodiazepine–Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site

Brucoli, Federico, Hawkins, Rachel M., James, Colin H., Jackson, Paul J. M., Wells, Geoff, Jenkins, Terence C., Ellis, Tom, Kotecha, Minal, Hochhauser, Daniel, Hartley, John A., Howard, Philip W., Thu

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.80 MB

english, 2013

30

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

Bose, D. Subhas, Thompson, Andrew S., Ching, Jingshan, Hartley, John A., Berardini, Mark D., Jenkins, Terence C., Neidle, Stephen, Hurley, Laurence H., Thurston, David E.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 784 KB

english, 1992

31

Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity

Gregson, Stephen J., Howard, Philip W., Thurston, David E., Jenkins, Terence C., Kelland, Lloyd R.

Journal:

Chemical Communications

Year:

1999

Language:

english

File:

PDF, 143 KB

english, 1999

32

Alpha-1-Protease Inhibitor in Bronchial Asthma: Phenotypes and Biochemical Characteristics

Gaillard, M. Christine, Kilroe-Smith, Terence A., Nogueira, Claudina, Dunn, David, Jenkins, Trefor, Fine, Barbara, Kallenbach, Jeremy

Journal:

American Review of Respiratory Disease

Year:

1992

Language:

english

File:

PDF, 627 KB

english, 1992

33

ChemInform Abstract: Synthesis of the First Example of a C2-C3/C2′-C3′-endo Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepine Dimer.

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

2002

File:

PDF, 29 KB

2002

34

The Synthesis and Biological Activity of C2-Fluorinated Pyrrolo[2,1-c][1,4]benzodiazepines.

Ian A. O'Neil, Stephen Thompson, S. Barret Kalindjian, Terence C. Jenkins

Journal:

Year:

2004

File:

PDF, 125 KB

2004

35

Demonstration of two non-radiative pathways in the decay of luminescent complexes of ruthenium(II) in a variety of solvents

Stephen R. Allsopp, Alna Cox, Stephen H. Jenkins, Terence J. Kemp, Stephen M. Tunstall

Journal:

Chemical Physics Letters

Year:

1976

Language:

english

File:

PDF, 245 KB

english, 1976

36

Hydration and solution structure of d(CGCAAATTTGCG)2 and its complex with propamidine from NMR and molecular modelling

Andrew N Lane, Terence C Jenkins, Thomas A Frenkiel

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1997

Language:

english

File:

PDF, 512 KB

english, 1997

37

The role of the N-(hydroxymethyl)melamines as antitumour agents: Mechanism of action studies

Helen M. Coley, Natalie Brooks, David H. Phillips, Alan Hewer, Terence C. Jenkins, Michael Jarman, Ian R. Judson

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.13 MB

english, 1995

38

[American Institute of Aeronautics and Astronautics 2nd Space Logistics Symposium - Costa Mesa,CA,U.S.A. (03 October 1988 - 05 October 1988)] 2nd Space Logistics Symposium - Assessment of alternative strategic defense system support concepts with a simulation model

BURGER, JOHN, JENKINS, TERENCE

Year:

1988

Language:

english

File:

PDF, 483 KB

english, 1988

39

Biarylpyrimidines: a new class of ligand for high-order DNA recognitionElectronic supplementary information (ESI) available: experimental details of UV melting studies and example spectroscopic and analytical data. See http://www.rsc.org/suppdata/cc/b3/b301554h/

Murphy, Peter M., Phillips, Victoria A., Jennings, Sharon A., Garbett, Nichola C., Chaires, Jonathan B., Jenkins, Terence C., Wheelhouse, Richard T.

Journal:

Chemical Communications

Year:

2003

Language:

english

File:

PDF, 110 KB

english, 2003

40

ChemInform Abstract: Targeting Multi-Stranded DNA Structures

Terence C. Jenkins

Journal:

Year:

2000

File:

PDF, 24 KB

2000

41

Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition

Jackson, Paul J. M., James, Colin H., Jenkins, Terence C., Rahman, Khondaker M., Thurston, David E.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.30 MB

english, 2014

42

Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides

Bates, Paula J., Macaulay, Valentine M., McLean, Michael J., Jenkins, Terence C., Reszka, Anthony P., Laughton, Charles A., Neidle, Stephen

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 6.25 MB

english, 1995

43

Effect of C2/C3-endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Simona Barcella, Anthonia Nakamya, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 165 KB

english, 2000

44

Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties

Edwards, Karen J., Jenkins, Terence C., Neidle, Stephen

Journal:

Year:

1992

Language:

english

File:

PDF, 707 KB

english, 1992

45

Polyfunctional Radiosensitizers: V. Sensitization of Hypoxic Chinese Hamster Cells, V.79-753B, in Vitro by a Series of Bifunctional Nitroxyl Compounds

Barbara C. Millar, Terence C. Jenkins and E. Martin Fielden

Journal:

Radiation Research

Year:

1982

Language:

english

File:

PDF, 1.01 MB

english, 1982

46

Telomerase inhibitors for the treatment of cancer: the current perspective

Perry, Philip J, Arnold, John RP, Jenkins, Terence C

Journal:

Expert Opinion on Investigational Drugs

Year:

2001

Language:

english

File:

PDF, 221 KB

english, 2001

47

Crystal Structure of an Oligonucleotide Duplex Containing G·G Base Pairs: Influence of Mispairing on DNA Backbone Conformation

Jane V. Skelly, Karen J. Edwards, Terence C. Jenkins and Stephen Neidle

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 913 KB

english, 1993

48

The phosphate-group of dna as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer

Andrew R.J. Silver, Peter O'Neill, Terence C. Jenkins, Shona S. McNeil

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1986

Language:

english

File:

PDF, 391 KB

english, 1986

49

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Simona Barcella, Maqsood M. Yasin, Abigail A. Hurst, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

50

Genotoxic effects of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions

Alan Cabill, Terence C. Jenkins, Pamela Pickering, Ian N.H. White

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 804 KB

english, 1995

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